Dear Colleagues!

    We are pleased to present a new issue of the scientific and practical journal “Comorbidity Neurology”, which consistently addresses key directions in contemporary medicine. The structure of this issue reflects the current trajectory of medical development – the transition from an isolated view of diseases to an integrative model of comorbidity, in which each clinical condition is analyzed within a system of interconnected pathophysiological processes.
    Particular attention in this issue is devoted to the interaction between immunological and metabolic factors in metabolic syndrome. The data presented emphasize that chronic low-grade inflammation should be regarded not merely as an accompanying phenomenon, but as a key pathogenetic mechanism determining both somatic and neurological outcomes. 
Continuing the theme of systemic influences, this issue includes a comparative assessment of cognitive and functional impairments in patients with a history of cytomegalovirus infection. The use of the MMSE, IADL, and FAB scales makes it possible to comprehensively characterize global cognitive status, executive functions, and the level of daily activity. 
    A separate section is devoted to the neuropsychiatric aspects of comorbidity in autism spectrum disorders. The review highlights the high prevalence of coexisting neurological and psychiatric disturbances, which not only modify the clinical phenotype but also substantially affect therapeutic strategies. In this context, traditional approaches to the management of patients with autism spectrum disorders require reconsideration in favor of multidisciplinary models involving neurologists, psychiatrists, and related specialists. 
    The clinical cases presented in this issue illustrate the complexity of diagnosis at the intersection of medical specialties. The report of post-vaccination dysmorphopsia draws attention to diagnostic and ethical dilemmas, including the risk of overdiagnosing causal relationships. Similarly, the clinical case of Kennedy disease demonstrates the importance of timely recognition of rare neurodegenerative disorders and their comorbid manifestations, where delayed diagnosis directly affects patients’ quality of life. 
   The practice-oriented core of this issue is the treatment algorithm for chronic nonspecific low back pain. It reflects current principles of patient stratification, the rational use of pharmacological and non-pharmacological methods, and patient routing in real-world clinical practice. At the same time, the degree of treatment personalization and the possibility of integrating the biopsychosocial model into standard management algorithms remain matters of discussion. 
   Thus, this issue not only reflects the current state of science, but also creates a platform for professional discussion. Its materials raise a number of fundamental questions – from the validity of diagnostic tools to the limits of interpretation of clinical data – and thereby define directions for future research.

Regards, 
Editor-in-Chief of the Journal of "Comorbidity Neurology",
President of the National Association of Experts in Comorbid Neurology,
Dr. Sci. (Med.), Professor Andrei P. Rachin